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In the context of early brain injury following subarachnoid hemorrhage (SAH), topiramate significantly reduced the elevated levels of TNF-, IL-1, and IL-6 induced by SAH, suggesting that topiramate may exert neuroprotection via its anti-inflammatory effects (Tian et al., 2015)

A 10 mg vial typically covers 2-5 weeks depending on the dose step

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The SURMOUNT-4 trial examined weight maintenance, showing that participants who continued tirzepatide after initial weight loss maintained and even extended their results, while those switched to placebo regained 14% of lost weight during the follow-up period

Life happens the cost becomes unsustainable or insurance drops coverage

The key qualifier is prior GLP-1 experience